In the near future, Matt Mills, a paraplegic prison inmate, meets the "Board" of Satoshi-Telefair Industries. They thank him for joining the Program and promise to make him walk again under pressure. Mills agrees to volunteer and is injected with a synthetic nanomaterial that suffocates him, only to wake up with restored use of his legs in a steel cell in the first spoke of an experimental apparatus - The Wheel.
A series of assailants inflict a multitude of damage to Mills' body and torment his mind, but the synthetic nanomaterial not only restores his damaged organs, it re-engineers his strength. The experiment might be designed to kill, but Mills is determined to survive - and get back to his daughter before The Board finds her first.